Ederson is out with Covid-19, so the American goalkeeper Zack Steffen will make his Premier League debut for Manchester City. Nathan Ake, Ferran Torres, Aymeric Laporte, Eric Garcia, Kyle Walker, Gabriel Jesus and Tommy Doyle are also missing from the squad. Ake and Laporte are injured; the rest have tested positive for Covid.
The superb Hakim Ziyech returns to the Chelsea team, and Timo Werner gets a start at centre-forward. Olivier Giroud, Callum Hudson-Odoi, Jorginho, Anthony Rudiger and Andreas Christensen, who started the 1-1 draw against Villa last year, are left out.
Chelsea (4-3-3) Mendy; Azpilicueta, Zouma, Thiago, Chilwell; Kovacic, Kante, Mount; Ziyech, Werner, Pulisic.
Substitutes: Kepa, Rudiger, Emerson, Jorginho, Gilmour, Havertz, Abraham, Giroud, Hudson-Odoi.
Manchester City (4-3-3) Steffen; Cancelo, Stones, Dias, Zinchecnko; Bernardo, Rodri, Gundogan; Sterling, De Bruyne, Foden.
Substitutes: Carson, Mendy, Harwood-Bells, Mbete, Fernandinho, Aguero, Mahrez, Delap.
Referee Anthony Taylor.