Liver cancer deaths have increased by around 50% in the last decade and have tripled since records began, according to the latest calculations by Cancer Research UK.
New mortality data shows that there were around 5,700 deaths from liver cancer in 2017 in the UK, which is the highest ever yearly number of deaths recorded. This has climbed from 3,200 deaths in
2007. Of all cancer types, liver cancer has had the largest increase in deaths over the last decade and the most rapid rise in deaths since UK records began.
Experts at Cancer Research UK believe that death rates have risen so steeply because the number of people being diagnosed with liver cancer has also increased — by 60% in the last decade — and survival is typically low. It’s one of the hardest cancers to treat, and five-year survival can range from anywhere between 6% and 37% depending on age and gender.
The disease is difficult to treat mainly because it can be hard to spot at an early stage as it often doesn’t cause symptoms until it has progressed. Because of this, emergency presentations are the most common route to diagnosing liver cancer and surgery isn’t an option for many of these patients because the disease has already spread. Clinicians find that many patients also have chronic liver disease, so symptoms of cancer can be easily missed.
While there are several factors affecting liver cancer risk, being overweight or obese and smoking are two of the biggest preventable causes. 23% of liver cancer cases can be linked to being overweight or obese, and 20% can be linked to smoking. Overall, around half of cases are preventable.
Cancer Research UK’s liver cancer expert, Professor Helen Reeves at Newcastle University, said: “Unfortunately, progress in treating liver cancer has been painfully slow and we desperately need more options for patients. Another problem is the rise in the number of people being diagnosed, which has meant we are losing more people to this disease than ever before.
“Rising levels of obesity and associated conditions like diabetes and non-alcoholic fatty liver disease have likely had a big role in this, although they aren’t the only factors.
“But the good news is that there are some potentially game-changing treatments on the way. Research looking at refining immunotherapy has been hugely promising. It doesn’t work in all patients just yet and we’re still looking at why that is, but it can add years to lives when it does.”
Every year, around 5,900 people are diagnosed with liver cancer in the UK. And this number is projected to rise by 38% in the UK between 2014 and 2035. Although liver cancer can happen at any age, it is most common in older people over the age of 60. And it’s more common in Asian and Black people.
Cancer Research UK’s chief executive Michelle Mitchell said: “A lot of progress has been made saving lives from cancer, but it’s worrying to see deaths from liver cancer increasing at such an alarming rate. Far too many lives are being lost, which is why we’re funding more research into this area. And aiming to understand more about the biology of the disease to develop better treatments.
“There are things we can all do to make a difference to our cancer risk and it’s never too late to make a change. Keeping a healthy weight, not smoking, and drinking less alcohol will all help lower your chance of developing liver cancer.”
*Percentage change in rates in past decade calculated by comparing 2005-2007 vs 2015-2017. UK-level incidence data first became available in 1971
Materials provided by Cancer Research UK. Note: Content may be edited for style and length.